This report summarizes the results of a survey on challenges for promoting utilization of toxicity prediction systems conducted by the Ministry of Economy, Trade and Industry in FY 2024.
In chemical substance safety assessment, computer-based toxicity prediction systems (QSAR, etc.) are gaining worldwide attention as new methods to replace animal testing. These systems are important technologies that enable efficient and economical safety assessment not only from animal welfare perspectives.
This survey conducted detailed analysis of development and utilization status of toxicity prediction systems domestically and internationally, acceptance status by regulatory authorities, and implementation cases in industry. Additionally, technical challenges including system accuracy improvement, database enhancement, and standardization promotion were also examined.
Survey results revealed that while the technical maturity of toxicity prediction systems has improved, challenges still exist in formal approval procedures by regulatory authorities and practical implementation in industry. Particularly, ensuring reliability of prediction accuracy, clarifying application scope, and international standardization were identified as important challenges.
Additionally, it was confirmed that strengthening cooperation among regulatory authorities, industry, and academic institutions, enhancing human resource development, and promoting international coordination are necessary for promoting system utilization.
The survey results are expected to be utilized as important reference materials for future chemical substance management policies and development of toxicity assessment technologies.